Agammaglobulinaemia and Selective Immunoglobulin Isotype Deficiencies

Abstract: A 9 page paper discussing X-linked agammaglobulinaemia (XLA), an immunodeficiency in which mature B lymphocyte cells fail to develop and Ig heavy chain rearrangement fails to progress as it should. The paper also discusses X-linked Hyper IgM Syndrome. Both conditions can result in decreased levels of IgA, IgG and IgE. XLA has been associated with greater incidence of colorectal cancer in young adults, but researchers are unclear whether the increase is related to a life history of greater incidence of infection. Many XLA patients died before reaching their 20s and 30s in years past, but better treatments are improving their chances. Includes 2 figures, bibliography lists 11 sources.

Filename: KSAgamma.doc

Pages: 9

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Catagory: Disease, Treatment, & Epidemiology

Subcatagory: Medicine, Medical Issues, & Pharmacy

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